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The Risk-Escalation Model: A Principled Design Strategy for Early-Phase Trials
Should first-in-human trials be designed to maximize the prospect of therapeutic benefit for volunteers, prioritize avoidance of unintended harms, or aim for some happy medium between the two? Perennial controversies surrounding initiation and design of early-phase trials hinge on how this question...
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| Publicado no: | Kennedy Inst Ethics J |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4482673/ https://ncbi.nlm.nih.gov/pubmed/25109092 |
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