Mechanisms underlying clinical efficacy of Angiotensin II type 2 receptor (AT(2)R) antagonist EMA401 in neuropathic pain: clinical tissue and in vitro studies

BACKGROUND: The clinical efficacy of the Angiotensin II (AngII) receptor AT(2)R antagonist EMA401, a novel peripherally-restricted analgesic, was reported recently in post-herpetic neuralgia. While previous studies have shown that AT(2)R is expressed by nociceptors in human DRG (hDRG), and that EMA4...

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Vydáno v:Mol Pain
Hlavní autoři: Anand, Uma, Yiangou, Yiangos, Sinisi, Marco, Fox, Michael, MacQuillan, Anthony, Quick, Tom, Korchev, Yuri E, Bountra, Chas, McCarthy, Tom, Anand, Praveen
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482278/
https://ncbi.nlm.nih.gov/pubmed/26111701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12990-015-0038-x
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