Mycolactone-mediated neurite degeneration and functional effects in cultured human and rat DRG neurons: Mechanisms underlying hypoalgesia in Buruli ulcer

BACKGROUND: Mycolactone is a polyketide toxin secreted by the mycobacterium Mycobacterium ulcerans, responsible for the extensive hypoalgesic skin lesions characteristic of patients with Buruli ulcer. A recent pre-clinical study proposed that mycolactone may produce analgesia via activation of the a...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Pain
Hauptverfasser: Anand, U, Sinisi, M, Fox, M, MacQuillan, A, Quick, T, Korchev, Y, Bountra, C, McCarthy, T, Anand, P
Format: Artigo
Sprache:Inglês
Veröffentlicht: SAGE Publications 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4956182/
https://ncbi.nlm.nih.gov/pubmed/27325560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1744806916654144
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