Splicing of many human genes involves sites embedded within introns

The conventional model for splicing involves excision of each intron in one piece; we demonstrate this inaccurately describes splicing in many human genes. First, after switching on transcription of SAMD4A, a gene with a 134 kb-long first intron, splicing joins the 3′ end of exon 1 to successive poi...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Kelly, Steven, Georgomanolis, Theodore, Zirkel, Anne, Diermeier, Sarah, O'Reilly, Dawn, Murphy, Shona, Längst, Gernot, Cook, Peter R., Papantonis, Argyris
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2015
Soggetti:
RNA
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482092/
https://ncbi.nlm.nih.gov/pubmed/25897131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv386
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