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The effect of RNA base lesions on mRNA translation

The biological effect of oxidatively damaged RNA, unlike oxidatively damaged DNA, has rarely been investigated, although it poses a threat to any living cell. Here we report on the effect of the commonly known RNA base-lesions 8-oxo-rG, 8-oxo-rA, ε-rC, ε-rA, 5-HO-rC, 5-HO-rU and the RNA abasic site...

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Publicat a:Nucleic Acids Res
Autors principals: Calabretta, Alessandro, Küpfer, Pascal A., Leumann, Christian J.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2015
Matèries:
RNA
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482091/
https://ncbi.nlm.nih.gov/pubmed/25897124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv377
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