Translation of the FMR1 mRNA is not influenced by AGG interruptions

The fragile X mental retardation 1 (FMR1) gene contains a CGG-repeat element within its 5′ untranslated region (5′UTR) which, for alleles with more than ∼40 repeats, increasingly affects both transcription (up-regulation) and translation (inhibition) of the repeat-containing RNA with increasing CGG-...

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Bibliographische Detailangaben
Hauptverfasser: Ludwig, Anna L., Raske, Christopher, Tassone, Flora, Garcia-Arocena, Dolores, Hershey, John W., Hagerman, Paul J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2009
Schlagworte:
RNA
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777427/
https://ncbi.nlm.nih.gov/pubmed/19752155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp713
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