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The Role of AGG Interruptions in the Transcription of FMR1 Premutation Alleles
Fragile X associated disorders are caused by a premutation allele in the fragile X mental retardation 1 gene (FMR1) and are hypothesized to result from the toxic effect of elevated levels of expanded FMR1 transcripts. Increased levels of FMR1 mRNA have indeed been reported in premutation carriers; h...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3139575/ https://ncbi.nlm.nih.gov/pubmed/21818263 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021728 |
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