A block in both early T lymphocyte and natural killer cell development in transgenic mice with high-copy numbers of the human CD3E gene.

A severe immunodeficiency involving a complete loss of T lymphocytes and natural killer cells was observed in independent lines of transgenic mice containing > 30 copies of the human CD3E gene (pL12). T-cell- natural killer (NK)- mice could also be generated by using a gene fragment pL12 delta 1...

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Hlavní autoři: Wang, B, Biron, C, She, J, Higgins, K, Sunshine, M J, Lacy, E, Lonberg, N, Terhorst, C
Médium: Artigo
Jazyk:Inglês
Vydáno: 1994
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC44820/
https://ncbi.nlm.nih.gov/pubmed/7937778
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