Transgene Expression Is Associated with Copy Number and Cytomegalovirus Promoter Methylation in Transgenic Pigs

Transgenic animals have been used for years to study gene function, produce important proteins, and generate models for the study of human diseases. However, inheritance and expression instability of the transgene in transgenic animals is a major limitation. Copy number and promoter methylation are...

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Main Authors: Kong, Qingran, Wu, Meiling, Huan, Yanjun, Zhang, Li, Liu, Haiyan, Bou, Gerelchimeg, Luo, Yibo, Mu, Yanshuang, Liu, Zhonghua
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2723931/
https://ncbi.nlm.nih.gov/pubmed/19688097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006679
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