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Nuclear factor-κB signaling and ezrin are essential for L1-mediated metastasis of colon cancer cells

Hyperactivation of β-catenin–T-cell-factor (TCF)-regulated gene transcription is a hallmark of colorectal cancer (CRC). The cell-neural adhesion molecule L1CAM (hereafter referred to as L1) is a target of β-catenin–TCF, exclusively expressed at the CRC invasive front in humans. L1 overexpression in...

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Podrobná bibliografie
Vydáno v:J Cell Sci
Hlavní autoři: Gavert, Nancy, Ben-Shmuel, Amir, Lemmon, Vance, Brabletz, Thomas, Ben-Ze'ev, Avri
Médium: Artigo
Jazyk:Inglês
Vydáno: Company of Biologists 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4481617/
https://ncbi.nlm.nih.gov/pubmed/20501702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.069542
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