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Nuclear factor-κB signaling and ezrin are essential for L1-mediated metastasis of colon cancer cells

Hyperactivation of β-catenin–T-cell-factor (TCF)-regulated gene transcription is a hallmark of colorectal cancer (CRC). The cell-neural adhesion molecule L1CAM (hereafter referred to as L1) is a target of β-catenin–TCF, exclusively expressed at the CRC invasive front in humans. L1 overexpression in...

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Detalles Bibliográficos
Publicado en:J Cell Sci
Main Authors: Gavert, Nancy, Ben-Shmuel, Amir, Lemmon, Vance, Brabletz, Thomas, Ben-Ze'ev, Avri
Formato: Artigo
Idioma:Inglês
Publicado: Company of Biologists 2010
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4481617/
https://ncbi.nlm.nih.gov/pubmed/20501702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.069542
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