Inducible caspase-9 suicide gene controls adverse effects from alloreplete T cells after haploidentical stem cell transplantation

To test the feasibility of a single T-cell manipulation to eliminate alloreactivity while sparing antiviral and antitumor T cells, we infused 12 haploidentical hematopoietic stem cell transplant patients with increasing numbers of alloreplete haploidentical T cells expressing the inducible caspase 9...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Blood
Päätekijät: Zhou, Xiaoou, Dotti, Gianpietro, Krance, Robert A., Martinez, Caridad A., Naik, Swati, Kamble, Rammurti T., Durett, April G., Dakhova, Olga, Savoldo, Barbara, Di Stasi, Antonio, Spencer, David M., Lin, Yu-Feng, Liu, Hao, Grilley, Bambi J., Gee, Adrian P., Rooney, Cliona M., Heslop, Helen E., Brenner, Malcolm K.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Hematology 2015
Aiheet:
Transplantation
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4481597/
https://ncbi.nlm.nih.gov/pubmed/25977584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-02-628354
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