Clinical and pharmacodynamic analysis of pomalidomide dosing strategies in myeloma: impact of immune activation and cereblon targets

In preclinical studies, pomalidomide mediated both direct antitumor effects and immune activation by binding cereblon. However, the impact of drug-induced immune activation and cereblon/ikaros in antitumor effects of pomalidomide in vivo is unknown. Here we evaluated the clinical and pharmacodynamic...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Sehgal, Kartik, Das, Rituparna, Zhang, Lin, Verma, Rakesh, Deng, Yanhong, Kocoglu, Mehmet, Vasquez, Juan, Koduru, Srinivas, Ren, Yan, Wang, Maria, Couto, Suzana, Breider, Mike, Hansel, Donna, Seropian, Stuart, Cooper, Dennis, Thakurta, Anjan, Yao, Xiaopan, Dhodapkar, Kavita M., Dhodapkar, Madhav V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4481593/
https://ncbi.nlm.nih.gov/pubmed/25869284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-11-611426
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