Genetic disruption of uncoupling protein 1 in mice renders brown adipose tissue a significant source of FGF21 secretion

OBJECTIVE: Circulating fibroblast growth factor 21 (FGF21) is an important auto- and endocrine player with beneficial metabolic effects on obesity and diabetes. In humans, thermogenic brown adipose tissue (BAT) was recently suggested as a source of FGF21 secretion during cold exposure. Here, we aim...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Keipert, Susanne, Kutschke, Maria, Lamp, Daniel, Brachthäuser, Laura, Neff, Frauke, Meyer, Carola W., Oelkrug, Rebecca, Kharitonenkov, Alexei, Jastroch, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
Assuntos:
Brief Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4481421/
https://ncbi.nlm.nih.gov/pubmed/26137441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2015.04.006
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