Production of extrachromosomal microDNAs is linked to mismatch repair pathways and transcriptional activity

MicroDNAs are <400-base extrachromosomal circles found in mammalian cells. Tens of thousands of microDNAs have been found in all tissue types, including sperm. MicroDNAs arise preferentially from areas with high gene density, GC content, and exon density, from promoters with activating chromatin...

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Pubblicato in:Cell Rep
Autori principali: Dillon, Laura W., Kumar, Pankaj, Shibata, Yoshiyuki, Wang, Yuh-Hwa, Willcox, Smaranda, Griffith, Jack D., Pommier, Yves, Takeda, Shunichi, Dutta, Anindya
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4481157/
https://ncbi.nlm.nih.gov/pubmed/26051933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.05.020
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