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ATAC-seq identifies thousands of extrachromosomal circular DNA in cancer and cell lines

Extrachromosomal circular DNAs (eccDNAs) are somatically mosaic and contribute to intercellular heterogeneity in normal and tumor cells. Because short eccDNAs are poorly chromatinized, we hypothesized that they are sequenced by tagmentation in ATAC-seq experiments without any enrichment of circular...

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Библиографические подробности
Опубликовано в: :Sci Adv
Главные авторы: Kumar, Pankaj, Kiran, Shashi, Saha, Shekhar, Su, Zhangli, Paulsen, Teressa, Chatrath, Ajay, Shibata, Yoshiyuki, Shibata, Etsuko, Dutta, Anindya
Формат: Artigo
Язык:Inglês
Опубликовано: American Association for the Advancement of Science 2020
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7228742/
https://ncbi.nlm.nih.gov/pubmed/32440553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba2489
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