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ATAC-seq identifies thousands of extrachromosomal circular DNA in cancer and cell lines
Extrachromosomal circular DNAs (eccDNAs) are somatically mosaic and contribute to intercellular heterogeneity in normal and tumor cells. Because short eccDNAs are poorly chromatinized, we hypothesized that they are sequenced by tagmentation in ATAC-seq experiments without any enrichment of circular...
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| Veröffentlicht in: | Sci Adv |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Association for the Advancement of Science
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7228742/ https://ncbi.nlm.nih.gov/pubmed/32440553 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba2489 |
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