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ATAC-seq identifies thousands of extrachromosomal circular DNA in cancer and cell lines

Extrachromosomal circular DNAs (eccDNAs) are somatically mosaic and contribute to intercellular heterogeneity in normal and tumor cells. Because short eccDNAs are poorly chromatinized, we hypothesized that they are sequenced by tagmentation in ATAC-seq experiments without any enrichment of circular...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Kumar, Pankaj, Kiran, Shashi, Saha, Shekhar, Su, Zhangli, Paulsen, Teressa, Chatrath, Ajay, Shibata, Yoshiyuki, Shibata, Etsuko, Dutta, Anindya
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7228742/
https://ncbi.nlm.nih.gov/pubmed/32440553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba2489
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