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CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line.

T lymphocytes require two signals to be activated. The antigen-specific T-cell receptor can deliver the first signal, while ligation of the T-cell surface molecule CD28 by antibodies or its cognate ligands B7-1 (CD80) or B7-2 has been demonstrated to be sufficient for the delivery of the second sign...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: August, A, Gibson, S, Kawakami, Y, Kawakami, T, Mills, G B, Dupont, B
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1994
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC44809/
https://ncbi.nlm.nih.gov/pubmed/7524075
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