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Systems Pharmacology Modeling Predicts Delayed Presentation and Species Differences in Bile Acid-Mediated Troglitazone Hepatotoxicity

Troglitazone (TGZ) caused delayed, life-threatening drug-induced liver injury (DILI) in some patients, but was not hepatotoxic in rats. This study investigated altered bile acid (BA) homeostasis as a mechanism of TGZ hepatotoxicity using a systems pharmacology model incorporating drug/metabolite dis...

詳細記述

保存先:
書誌詳細
出版年:Clin Pharmacol Ther
主要な著者: Yang, Kyunghee, Woodhead, Jeffrey L, Watkins, Paul B, Howell, Brett A, Brouwer, Kim LR
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4480860/
https://ncbi.nlm.nih.gov/pubmed/25068506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2014.158
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