TP53 intron 1 hotspot rearrangements are specific to sporadic osteosarcoma and can cause Li-Fraumeni syndrome

Somatic mutations of TP53 are among the most common in cancer and germline mutations of TP53 (usually missense) can cause Li-Fraumeni syndrome (LFS). Recently, recurrent genomic rearrangements in intron 1 of TP53 have been described in osteosarcoma (OS), a highly malignant neoplasm of bone belonging...

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Библиографические подробности
Опубликовано в: :Oncotarget
Главные авторы: Ribi, Sebastian, Baumhoer, Daniel, Lee, Kristy, Edison, Teo, Audrey S.M., Madan, Babita, Zhang, Kang, Kohlmann, Wendy K., Yao, Fei, Lee, Wah Heng, Hoi, Qiangze, Cai, Shaojiang, Woo, Xing Yi, Tan, Patrick, Jundt, Gernot, Smida, Jan, Nathrath, Michaela, Sung, Wing-Kin, Schiffman, Joshua D., Virshup, David M., Hillmer, Axel M.
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2015
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4480712/
https://ncbi.nlm.nih.gov/pubmed/25762628
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