Mechanical overloading causes mitochondrial superoxide and SOD2 imbalance in chondrocytes resulting in cartilage degeneration

Mechanical stress and aging are major risk factors of cartilage degeneration. Human studies have previously reported that oxidative damage increased, while SOD2 protein was reciprocally downregulated in osteoarthritic degenerated cartilage. However, it remains unclear whether mitochondrial superoxid...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Koike, Masato, Nojiri, Hidetoshi, Ozawa, Yusuke, Watanabe, Kenji, Muramatsu, Yuta, Kaneko, Haruka, Morikawa, Daichi, Kobayashi, Keiji, Saita, Yoshitomo, Sasho, Takahisa, Shirasawa, Takuji, Yokote, Koutaro, Kaneko, Kazuo, Shimizu, Takahiko
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4480010/
https://ncbi.nlm.nih.gov/pubmed/26108578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep11722
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