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Sod1 Loss Induces Intrinsic Superoxide Accumulation Leading to p53-Mediated Growth Arrest and Apoptosis
Oxidative damages induced by a redox imbalance cause age-related changes in cells and tissues. Superoxide dismutase (SOD) enzymes play a major role in the antioxidant system and they also catalyze superoxide radicals (O(2)(•−)). Since the loss of cytoplasmic SOD (SOD1) resulted in aging-like phenoty...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Molecular Diversity Preservation International (MDPI)
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3709714/ https://ncbi.nlm.nih.gov/pubmed/23708100 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms140610998 |
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