Sod1 Loss Induces Intrinsic Superoxide Accumulation Leading to p53-Mediated Growth Arrest and Apoptosis

Oxidative damages induced by a redox imbalance cause age-related changes in cells and tissues. Superoxide dismutase (SOD) enzymes play a major role in the antioxidant system and they also catalyze superoxide radicals (O(2)(•−)). Since the loss of cytoplasmic SOD (SOD1) resulted in aging-like phenoty...

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Main Authors: Watanabe, Kenji, Shibuya, Shuichi, Koyama, Hirofumi, Ozawa, Yusuke, Toda, Toshihiko, Yokote, Koutaro, Shimizu, Takahiko
Formato: Artigo
Idioma:Inglês
Publicado: Molecular Diversity Preservation International (MDPI) 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3709714/
https://ncbi.nlm.nih.gov/pubmed/23708100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms140610998
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