Considerably Unfolded Transthyretin Monomers Preceed and Exchange with Dynamically Structured Amyloid Protofibrils

Despite numerous studies, a detailed description of the transthyretin (TTR) self-assembly mechanism and fibril structure in TTR amyloidoses remains unresolved. Here, using a combination of primarily small -angle X-ray scattering (SAXS) and hydrogen exchange mass spectrometry (HXMS) analysis, we desc...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Groenning, Minna, Campos, Raul I., Hirschberg, Daniel, Hammarström, Per, Vestergaard, Bente
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4480009/
https://ncbi.nlm.nih.gov/pubmed/26108284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep11443
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