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Leukemogenic rearrangements at the mixed lineage leukemia gene (MLL)—multiple rather than a single mechanism

Despite manifold efforts to achieve reduced-intensity and -toxicity regimens, secondary leukemia has remained the most severe side effect of chemotherapeutic cancer treatment. Rearrangements involving a short telomeric <1 kb region of the mixed lineage leukemia (MLL) gene are the most frequently...

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Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: Gole, Boris, Wiesmüller, Lisa
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4479792/
https://ncbi.nlm.nih.gov/pubmed/26161385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2015.00041
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