High-Throughput Screening to Identify Compounds That Increase Fragile X Mental Retardation Protein Expression in Neural Stem Cells Differentiated From Fragile X Syndrome Patient-Derived Induced Pluripotent Stem Cells

Fragile X syndrome (FXS), the most common form of inherited cognitive disability, is caused by a deficiency of the fragile X mental retardation protein (FMRP). In most patients, the absence of FMRP is due to an aberrant transcriptional silencing of the fragile X mental retardation 1 (FMR1) gene. FXS...

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Dettagli Bibliografici
Pubblicato in:Stem Cells Transl Med
Autori principali: Kumari, Daman, Swaroop, Manju, Southall, Noel, Huang, Wenwei, Zheng, Wei, Usdin, Karen
Natura: Artigo
Lingua:Inglês
Pubblicazione: AlphaMed Press 2015
Soggetti:
Cell-Based Drug Development, Screening, and Toxicology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4479623/
https://ncbi.nlm.nih.gov/pubmed/25999519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5966/sctm.2014-0278
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