PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling

In the liver, insulin-mediated activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway is at the core of metabolic control. Multiple PI3K and Akt isoenzymes are found in hepatocytes and whether isoform-selective interplays exist is currently unclear. Here we report that insulin signalling...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Nat Commun
Главные авторы: Braccini, Laura, Ciraolo, Elisa, Campa, Carlo C., Perino, Alessia, Longo, Dario L., Tibolla, Gianpaolo, Pregnolato, Marco, Cao, Yanyan, Tassone, Beatrice, Damilano, Federico, Laffargue, Muriel, Calautti, Enzo, Falasca, Marco, Norata, Giuseppe D., Backer, Jonathan M., Hirsch, Emilio
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Pub. Group 2015
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4479417/
https://ncbi.nlm.nih.gov/pubmed/26100075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8400
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы