In vivo imaging using fluorescent antibodies to tumor necrosis factor predicts therapeutic response in Crohn’s disease

As antibodies to tumor necrosis factor (TNF) suppress immune responses in Crohn’s disease by binding to membrane-bound TNF (mTNF), we created a fluorescent antibody for molecular mTNF imaging in this disease. Topical antibody administration in 25 patients with Crohn’s disease led to detection of int...

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Detalhes bibliográficos
Publicado no:Nat Med
Main Authors: Atreya, Raja, Neumann, Helmut, Neufert, Clemens, Waldner, Maximilian J, Billmeier, Ulrike, Zopf, Yurdagül, Willma, Marcus, App, Christine, Münster, Tino, Kessler, Hermann, Maas, Stefanie, Gebhardt, Bernd, Heimke-Brinck, Ralph, Reuter, Eva, Dörje, Frank, Rau, Tilman T, Uter, Wolfgang, Wang, Thomas D, Kiesslich, Ralf, Vieth, Michael, Hannappel, Ewald, Neurath, Markus F
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4479137/
https://ncbi.nlm.nih.gov/pubmed/24562382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3462
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