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Lipophilic prodrug conjugates allow facile and rapid synthesis of high loading capacity liposomes without the need for post-assembly purification

Dihydropyridopyrazoles are simplified synthetic analogues of podophyllotoxin that can effectively mimic its molecular scaffold and act as potent mitotic spindle poisons in dividing cancer cells. However, despite nanomolar potencies and ease of synthetic preparation, further clinical development of t...

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Bibliografske podrobnosti
izdano v:J Liposome Res
Main Authors: Mikhalin, Alexander A., Evdokimov, Nikolai M., Frolova, Liliya V., Magedov, Igor V., Kornienko, Alexander, Johnston, Robert, Rogelj, Snezna, Tartis, Michaelann S.
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4478286/
https://ncbi.nlm.nih.gov/pubmed/25534989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/08982104.2014.992022
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