Lipophilic prodrug conjugates allow facile and rapid synthesis of high loading capacity liposomes without the need for post-assembly purification

Dihydropyridopyrazoles are simplified synthetic analogues of podophyllotoxin that can effectively mimic its molecular scaffold and act as potent mitotic spindle poisons in dividing cancer cells. However, despite nanomolar potencies and ease of synthetic preparation, further clinical development of t...

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Vydáno v:J Liposome Res
Hlavní autoři: Mikhalin, Alexander A., Evdokimov, Nikolai M., Frolova, Liliya V., Magedov, Igor V., Kornienko, Alexander, Johnston, Robert, Rogelj, Snezna, Tartis, Michaelann S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4478286/
https://ncbi.nlm.nih.gov/pubmed/25534989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/08982104.2014.992022
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