Epigenetic priming of enhancers predicts developmental competence of hESC-derived endodermal lineage intermediates

Embryonic development relies on the capacity of progenitor cells to appropriately respond to inductive cues; a cellular property known as developmental competence. Here we report that epigenetic priming of enhancers signifies developmental competence during endodermal lineage diversification. Chroma...

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Veröffentlicht in:Cell Stem Cell
Hauptverfasser: Wang, Allen, Yue, Feng, Li, Yan, Xie, Ruiyu, Harper, Thomas, Patel, Nisha A., Muth, Kayla, Palmer, Jeffrey, Qiu, Yunjiang, Wang, Jinzhao, Lam, Dieter K., Raum, Jeffrey C., Stoffers, Doris A., Ren, Bing, Sander, Maike
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4478079/
https://ncbi.nlm.nih.gov/pubmed/25842977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2015.02.013
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