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High Mitochondrial Priming Sensitizes hESCs to DNA-Damage-Induced Apoptosis
Human embryonic stem cells (hESCs) are highly sensitive to DNA damage and have low survival ability relative to differentiated cells. We investigated the source of this difference by comparing damage response pathways in hESCs and differentiated cells. We found that hESCs undergo more rapid p53-depe...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4109647/ https://ncbi.nlm.nih.gov/pubmed/23954752 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2013.07.018 |
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