High Mitochondrial Priming Sensitizes hESCs to DNA-Damage-Induced Apoptosis

Human embryonic stem cells (hESCs) are highly sensitive to DNA damage and have low survival ability relative to differentiated cells. We investigated the source of this difference by comparing damage response pathways in hESCs and differentiated cells. We found that hESCs undergo more rapid p53-depe...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Liu, Julia C., Guan, Xiao, Ryan, Jeremy A., Rivera, Ana G., Mock, Caroline, Agrawal, Vishesh, Letai, Anthony, Lerou, Paul H., Lahav, Galit
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2013
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4109647/
https://ncbi.nlm.nih.gov/pubmed/23954752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2013.07.018
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