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A CRISPR Connection between Chromatin Topology and Genetic Disorders
Structural variations are common in the human genome but their contributions to human diseases have been hard to define. Lupiáñez et al demonstrate that some structural variants can interrupt chromatin topology, resulting in ectopic enhancer-promoter interactions, altered spatiotemporal gene express...
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| Publié dans: | Cell |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4478077/ https://ncbi.nlm.nih.gov/pubmed/26000472 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.04.047 |
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