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A CRISPR Connection between Chromatin Topology and Genetic Disorders
Structural variations are common in the human genome but their contributions to human diseases have been hard to define. Lupiáñez et al demonstrate that some structural variants can interrupt chromatin topology, resulting in ectopic enhancer-promoter interactions, altered spatiotemporal gene express...
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| Publicado no: | Cell |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4478077/ https://ncbi.nlm.nih.gov/pubmed/26000472 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.04.047 |
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