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Lipid nanoparticle delivery of a microRNA-145 inhibitor improves experimental pulmonary hypertension

Therapies that exploit RNA interference (RNAi) hold great potential for improving disease outcomes. However, there are several challenges that limit the application of RNAi therapeutics. One of the most important challenges is effective delivery of oligonucleotides to target cells and reduced delive...

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Detalhes bibliográficos
Publicado no:J Control Release
Main Authors: McLendon, Jared M., Joshi, Sachindra R., Sparks, Jeff, Matar, Majed, Fewell, Jason G., Abe, Kohtaro, Oka, Masahiko, McMurtry, Ivan F., Gerthoffer, William T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4477514/
https://ncbi.nlm.nih.gov/pubmed/25979327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2015.05.261
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