Nanoparticle Delivery of Anti-inflammatory LNA Oligonucleotides Prevents Airway Inflammation in a HDM Model of Asthma

To address the problem of poor asthma control due to drug resistance, an antisense oligonucleotide complementary to mmu-miR-145a-5p (antimiR-145) was tested in a house dust mite mouse model of mild/moderate asthma. miR-145 was targeted to reduce inflammation, regulate epithelial-mesenchymal transiti...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Ramelli, Sabrina C., Comer, Brian S., McLendon, Jared M., Sandy, Lydia L., Ferretti, Andrew P., Barrington, Robert, Sparks, Jeff, Matar, Majed, Fewell, Jason, Gerthoffer, William T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7013130/
https://ncbi.nlm.nih.gov/pubmed/32044723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2019.12.033
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