An integrated approach to reveal miRNAs’ impacts on the functional consequence of copy number alterations in cancer

Copy number alteration (CNA) is known to induce gene expression changes mainly through dosage effect, and therefore affect the initiation and progression of tumor. However, tumor samples exhibit heterogeneity in gene dosage sensitivity due to the complicated mechanisms of transcriptional regulation....

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Li, Kening, Liu, Yongjing, Zhou, Yuanshuai, Zhang, Rui, Zhao, Ning, Yan, Zichuang, Zhang, Qiang, Zhang, Shujuan, Qiu, Fujun, Xu, Yan
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4477324/
https://ncbi.nlm.nih.gov/pubmed/26099552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep11567
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