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Modulation of mTOR Activity by μ‐Opioid Receptor is Dependent upon the Association of Receptor and FK506‐Binding Protein 12

AIMS: Mechanistic/mammalian target of rapamycin (mTOR) activation by μ‐opioid receptor (OPRM1) participates in antinociceptive tolerance, hyperalgesia, and physical dependence. Our previous study also showed that mTOR activation by OPRM1 could attenuate β amyloid oligomers‐induced neurotoxicity. OPR...

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Detalles Bibliográficos
Publicado en:CNS Neurosci Ther
Main Authors: Wang, Yan, Ge, Yan‐Hui, Wang, Yan‐Xia, Liu, Ting, Law, Ping‐Yee, Loh, Horace H., Chen, Hong‐Zhuan, Qiu, Yu
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4477277/
https://ncbi.nlm.nih.gov/pubmed/26096047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.12409
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