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Role of FK506 binding protein 12 in morphine-induced μ-opioid receptor internalization and desensitization
Agonist-activated μ-opioid receptor (OPRM1) undergoes robust receptor phosphorylation by G protein-coupled receptor kinases and subsequent β-arrestin recruitment, triggering receptor internalization and desensitization. Morphine, a widely prescribed opioid, induces receptor phosphorylation inefficie...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4010564/ https://ncbi.nlm.nih.gov/pubmed/24607931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2014.02.059 |
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