Crystal structures of the human adiponectin receptors

Adiponectin stimulation of its receptors, AdipoR1 and AdipoR2, increases AMPK and PPAR activities, respectively, thereby contributing to healthy longevity as key anti-diabetic molecules. AdipoR1 and AdipoR2 were predicted to contain seven transmembrane helices with the opposite topology to G protein...

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Pubblicato in:Nature
Autori principali: Tanabe, Hiroaki, Fujii, Yoshifumi, Okada-Iwabu, Miki, Iwabu, Masato, Nakamura, Yoshihiro, Hosaka, Toshiaki, Motoyama, Kanna, Ikeda, Mariko, Wakiyama, Motoaki, Terada, Takaho, Ohsawa, Noboru, Hato, Masakatsu, Ogasawara, Satoshi, Hino, Tomoya, Murata, Takeshi, Iwata, So, Hirata, Kunio, Kawano, Yoshiaki, Yamamoto, Masaki, Kimura-Someya, Tomomi, Shirouzu, Mikako, Yamauchi, Toshimasa, Kadowaki, Takashi, Yokoyama, Shigeyuki
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4477036/
https://ncbi.nlm.nih.gov/pubmed/25855295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14301
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