The zinc-binding region (ZBR) fragment of Emi2 can inhibit APC/C by targeting its association with the coactivator Cdc20 and UBE2C-mediated ubiquitylation

Anaphase-promoting complex or cyclosome (APC/C) is a multisubunit ubiquitin ligase E3 that targets cell-cycle regulators. Cdc20 is required for full activation of APC/C in M phase, and mediates substrate recognition. In vertebrates, Emi2/Erp1/FBXO43 inhibits APC/C-Cdc20, and functions as a cytostati...

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Detalhes bibliográficos
Main Authors: Shoji, Shisako, Muto, Yutaka, Ikeda, Mariko, He, Fahu, Tsuda, Kengo, Ohsawa, Noboru, Akasaka, Ryogo, Terada, Takaho, Wakiyama, Motoaki, Shirouzu, Mikako, Yokoyama, Shigeyuki
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4141206/
https://ncbi.nlm.nih.gov/pubmed/25161877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fob.2014.06.010
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