Osteopontin Mediates an MZF1-TGF-β1-Dependent Transformation of Mesenchymal Stem Cells into Cancer Associated Fibroblasts in Breast Cancer

Interactions between tumor cells and cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TMEN) significantly influence cancer growth and metastasis. Transforming growth factor-β (TGF-β) is known to be a critical mediator of the CAF phenotype, and osteopontin (OPN) expression in tumor...

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Pubblicato in:Oncogene
Autori principali: Weber, Cynthia E., Kothari, Anai N., Wai, Philip Y., Li, Neill Y., Driver, Joseph, Zapf, Matthew A.C., Franzen, Carrie A., Gupta, Gopal N., Osipo, Clodio, Zlobin, Andrei, Syn, Wing Kin, Zhang, Jiwang, Kuo, Paul C., Mi, Zhiyong
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476970/
https://ncbi.nlm.nih.gov/pubmed/25531323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.410
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