Osteopontin Mediates an MZF1-TGF-β1-Dependent Transformation of Mesenchymal Stem Cells into Cancer Associated Fibroblasts in Breast Cancer

Interactions between tumor cells and cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TMEN) significantly influence cancer growth and metastasis. Transforming growth factor-β (TGF-β) is known to be a critical mediator of the CAF phenotype, and osteopontin (OPN) expression in tumor...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Weber, Cynthia E., Kothari, Anai N., Wai, Philip Y., Li, Neill Y., Driver, Joseph, Zapf, Matthew A.C., Franzen, Carrie A., Gupta, Gopal N., Osipo, Clodio, Zlobin, Andrei, Syn, Wing Kin, Zhang, Jiwang, Kuo, Paul C., Mi, Zhiyong
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476970/
https://ncbi.nlm.nih.gov/pubmed/25531323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.410
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