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Novel therapeutic approaches for hepatitis B virus covalently closed circular DNA

Hepatitis B virus (HBV) infection is a major global health problem. Although current therapies, such as the use of nucleos(t)ide analogs, inhibit HBV replication efficiently, they do not eliminate covalently closed circular DNA (cccDNA), which persists in hepatocyte nuclei. As HBV cccDNA is a viral...

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Detalhes bibliográficos
Publicado no:World J Gastroenterol
Main Authors: Ohno, Motoko, Otsuka, Motoyuki, Kishikawa, Takahiro, Yoshikawa, Takeshi, Takata, Akemi, Koike, Kazuhiko
Formato: Artigo
Idioma:Inglês
Publicado em: Baishideng Publishing Group Inc 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476870/
https://ncbi.nlm.nih.gov/pubmed/26109795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v21.i23.7084
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