Myosin VI Must Dimerize and Deploy Its Unusual Lever Arm in Order to Perform Its Cellular Roles

It is unclear if the reverse-direction myosin, myosin VI, functions as a monomer or dimer in cells and how it generates large movements on actin. We deleted a stable, single α-helix (SAH) domain that has been proposed to function as part of a lever arm to amplify movements, without impact on in vitr...

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Pubblicato in:Cell Rep
Autori principali: Mukherjea, Monalisa, Ali, M. Yusuf, Kikuti, Carlos, Safer, Daniel, Yang, Zhaohui, Sirkia, Helena, Ropars, Virginie, Houdusse, Anne, Warshaw, David M., Sweeney, H. Lee
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476653/
https://ncbi.nlm.nih.gov/pubmed/25159143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.07.041
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