NOS-2 Inhibition in Phosgene-Induced Acute Lung Injury

Phosgene exposure via an industrial or warfare release produces severe acute lung injury (ALI) with high mortality, characterized by massive pulmonary edema, disruption of epithelial tight junctions, surfactant dysfunction, and oxidative stress. There are no targeted treatments for phosgene-induced...

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Udgivet i:Toxicol Sci
Main Authors: Filipczak, Piotr T., Senft, Albert P., Seagrave, JeanClare, Weber, Waylon, Kuehl, Philip J., Fredenburgh, Laura E., McDonald, Jacob D., Baron, Rebecca M.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2015
Fag:
Attenuation of Phosgene-Induced Pulmonary Damage
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476462/
https://ncbi.nlm.nih.gov/pubmed/25870319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfv072
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