An N-terminal formyl methionine on COX 1 is required for the assembly of cytochrome c oxidase

Protein synthesis in mitochondria is initiated by formylmethionyl-tRNA(Met) (fMet-tRNA(Met)), which requires the activity of the enzyme MTFMT to formylate the methionyl group. We investigated the molecular consequences of mutations in MTFMT in patients with Leigh syndrome or cardiomyopathy. All pati...

Full description

Saved in:
Bibliographic Details
Published in:Hum Mol Genet
Main Authors: Hinttala, Reetta, Sasarman, Florin, Nishimura, Tamiko, Antonicka, Hana, Brunel-Guitton, Catherine, Schwartzentruber, Jeremy, Fahiminiya, Somayyeh, Majewski, Jacek, Faubert, Denis, Ostergaard, Elsebet, Smeitink, Jan A., Shoubridge, Eric A.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2015
Subjects:
Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476453/
https://ncbi.nlm.nih.gov/pubmed/25911677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv149
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items