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An N-terminal formyl methionine on COX 1 is required for the assembly of cytochrome c oxidase
Protein synthesis in mitochondria is initiated by formylmethionyl-tRNA(Met) (fMet-tRNA(Met)), which requires the activity of the enzyme MTFMT to formylate the methionyl group. We investigated the molecular consequences of mutations in MTFMT in patients with Leigh syndrome or cardiomyopathy. All pati...
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| Published in: | Hum Mol Genet |
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| Main Authors: | , , , , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Oxford University Press
2015
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4476453/ https://ncbi.nlm.nih.gov/pubmed/25911677 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv149 |
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