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Antioxidant and anti-inflammatory agents mitigate pathology in a mouse model of pseudoachondroplasia
Pseudoachondroplasia (PSACH), a severe short-limb dwarfing condition, results from mutations that cause misfolding of the cartilage oligomeric matrix protein (COMP). Accumulated COMP in growth plate chondrocytes activates endoplasmic reticulum stress, leading to inflammation and chondrocyte death. U...
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| Publicado no: | Hum Mol Genet |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4476442/ https://ncbi.nlm.nih.gov/pubmed/25859006 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv122 |
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