The preclinical pharmacology of the high affinity anti-IL-6R Nanobody® ALX-0061 supports its clinical development in rheumatoid arthritis

INTRODUCTION: The pleiotropic cytokine interleukin-6 (IL-6) plays an important role in the pathogenesis of different diseases, including rheumatoid arthritis (RA). ALX-0061 is a bispecific Nanobody® with a high affinity and potency for IL-6 receptor (IL-6R), combined with an extended half-life by ta...

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Publicat a:Arthritis Res Ther
Autors principals: Van Roy, Maarten, Ververken, Cedric, Beirnaert, Els, Hoefman, Sven, Kolkman, Joost, Vierboom, Michel, Breedveld, Elia, ‘t Hart, Bert, Poelmans, Sofie, Bontinck, Lieselot, Hemeryck, Alex, Jacobs, Sandy, Baumeister, Judith, Ulrichts, Hans
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476083/
https://ncbi.nlm.nih.gov/pubmed/25994180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-015-0651-0
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