Monitoring response to therapy in melanoma by quantifying circulating tumour DNA with droplet digital PCR for BRAF and NRAS mutations

We assessed the utility of droplet digital PCR (ddPCR) to evaluate the potential of using circulating tumour DNA (ctDNA) as a post therapy monitoring tool in melanoma by comparing it to serum LDH levels and RECIST scores. ddPCR was shown to be reliable in distinguishing mutant from wild type alleles...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Chang-Hao Tsao, Simon, Weiss, Jonathan, Hudson, Christopher, Christophi, Christopher, Cebon, Jonathan, Behren, Andreas, Dobrovic, Alexander
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476039/
https://ncbi.nlm.nih.gov/pubmed/26095797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep11198
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