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Monitoring response to therapy in melanoma by quantifying circulating tumour DNA with droplet digital PCR for BRAF and NRAS mutations

We assessed the utility of droplet digital PCR (ddPCR) to evaluate the potential of using circulating tumour DNA (ctDNA) as a post therapy monitoring tool in melanoma by comparing it to serum LDH levels and RECIST scores. ddPCR was shown to be reliable in distinguishing mutant from wild type alleles...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Chang-Hao Tsao, Simon, Weiss, Jonathan, Hudson, Christopher, Christophi, Christopher, Cebon, Jonathan, Behren, Andreas, Dobrovic, Alexander
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476039/
https://ncbi.nlm.nih.gov/pubmed/26095797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep11198
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